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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Christopher Carr <br>
<b>Subject: </b>UROP: Seeking life beyond Earth via single molecule detection<o:p></o:p></span></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Hi,<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">I'm a research scientist at MIT working with Prof. Maria Zuber and would like to advertise a UROP to the MIT Biology undergraduate community.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Details below and PDF attached.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">Christopher E. Carr, Sc.D.</span><span style="font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">Research Scientist, MIT<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">Research Fellow, MGH<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">chrisc@mit.edu<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif"><a href="https://www.cecarr.com/" target="_blank">https://www.cecarr.com/</a></span><span style="font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif"><a href="https://twitter.com/c_e_carr" target="_blank">https://twitter.com/c_e_carr</a></span><span style="font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif"><a href="tel:%2B1-617-253-0786" target="_blank">+1-617-253-0786</a> (office)<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif"><a href="tel:%2B1-617-643-2910" target="_blank">+1-617-643-2910</a> (lab)<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif"><a href="tel:%2B1-617-216-5012" target="_blank">+1-617-216-5012</a> (mobile)<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">Lab and shipping address:<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">MGH Mol Bio Simches Bldg<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">185 Cambridge St, CPZN7700<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">Boston, MA 02114, USA<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Arial",sans-serif">------<o:p></o:p></span></p>
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<span style="font-size:16.0pt;color:#345A8A">UROP: Seeking life beyond Earth via single molecule detection<o:p></o:p></span></h1>
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<span style="font-size:13.0pt;color:#4F81BD">Apply By<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica">March 6, 2020<o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Term<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica">Spring<o:p></o:p></span></p>
<h2 style="mso-margin-top-alt:10.0pt;margin-right:0in;margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;break-after:avoid">
<span style="font-size:13.0pt;color:#4F81BD">Department<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica">EAPS<o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">MIT Faculty Supervisor Name<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica">Maria T. Zuber<o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">MIT Faculty Supervisor E-mail<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica"><a href="mailto:zuber@mit.edu">zuber@mit.edu</a><o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Immediate Supervisor Name<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica">Christopher E. Carr<o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Immediate Supervisor E-mail<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica"><a href="mailto:chrisc@mit.edu">chrisc@mit.edu</a><o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Project Title<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica">Seeking life beyond Earth via single molecule detection<o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Project Description<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica">Our group is working on life detection instruments for Mars and Ocean Worlds utilizing single molecule detection, including 1) nanopore-based nucleic acid sequencing, and
2) fully electronic single molecule detection. Together, these two approaches will target life as we know it, and life as we don’t know it.<o:p></o:p></span></p>
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<span style="font-family:Helvetica">1)</span><span style="font-size:7.0pt;font-family:"Times New Roman",serif">
</span><span style="font-family:Helvetica">Contribute to engineering development of these life detection instruments through engineering design, fabrication, and testing (including in a thermal vacuum chamber and during a parabolic flight). Useful skills: SOLIDWORKS,
EAGLE or other printed circuit board design tools, soldering, circuit board assembly, microcontroller programming, 3d printing).<o:p></o:p></span></p>
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<b><span style="font-family:Helvetica">2)</span></b><span style="font-size:7.0pt;font-family:"Times New Roman",serif">
</span><b><span style="font-family:Helvetica">Carry out wet lab experiments to study organic biomarker preservation, extraction, and detection (hypersaline lakes; Atacama Desert; synthetic analogs of Mars).</span></b><span style="font-family:Helvetica"><o:p></o:p></span></p>
<p class="gmail-msolistparagraph" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;margin-bottom:.0001pt">
<b><span style="font-family:Helvetica">a.</span></b><span style="font-size:7.0pt;font-family:"Times New Roman",serif">
</span><b><span style="font-family:Helvetica">Evaluating DNA damage and DNA repair methods</span></b><span style="font-family:Helvetica"><o:p></o:p></span></p>
<p class="gmail-msolistparagraph" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;margin-bottom:.0001pt">
<b><span style="font-family:Helvetica">b.</span></b><span style="font-size:7.0pt;font-family:"Times New Roman",serif">
</span><b><span style="font-family:Helvetica">Applying them to environmental DNA</span></b><span style="font-family:Helvetica"><o:p></o:p></span></p>
<p class="gmail-msolistparagraph" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;margin-bottom:.0001pt">
<b><span style="font-family:Helvetica">c.</span></b><span style="font-size:7.0pt;font-family:"Times New Roman",serif">
</span><b><span style="font-family:Helvetica">Evaluating detection of damaged DNA bases via single molecule sequencing.</span></b><span style="font-family:Helvetica"><o:p></o:p></span></p>
<p class="gmail-msolistparagraph" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;margin-bottom:.0001pt">
<span style="font-family:Helvetica">3)</span><span style="font-size:7.0pt;font-family:"Times New Roman",serif">
</span><span style="font-family:Helvetica">Apply bioinformatics analyses to characterize the limits of life. Useful skills: Unix, Docker, python, MATLAB.<o:p></o:p></span></p>
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<span style="font-family:Helvetica">4)</span><span style="font-size:7.0pt;font-family:"Times New Roman",serif">
</span><span style="font-family:Helvetica">Use statistics and machine learning approaches to analyze single molecule data.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica;color:#1A1A1A">You will have an opportunity to work with an interdisciplinary team, to gain expertise in a variety of disciplines, to develop skills applicable to future research
and industry, carry out experiments, build hardware, test under space-like conditions, and ultimately, deploy space hardware. The sky is not the limit.</span><span style="font-family:Helvetica"><o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Prerequisites<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica;color:#1A1A1A">You must be highly motivated, technically excellent, with strong analytical and problem-solving skills, able to work independently and contribute to an interdisciplinary
team, and have excellent communication and interpersonal skills. Experience in aerospace / mechanical / electrical / biological engineering, biology, geology, or a related field is a plus. We also highly value creativity, drive, and dedication to the search
for life beyond Earth. Experience with molecular biology, embedded systems, microcontrollers, mechanical design, thermal modeling, space instrumentation, and other relevant skills valued but not required. First-year students welcome.</span><span style="font-family:Helvetica"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:10.0pt"><b><span style="font-family:Helvetica;color:#1A1A1A">Time Commitment and Location:</span></b><span style="font-family:Helvetica;color:#1A1A1A"> 10+ hours/week during semester, full-time during summer (if relevant),
based one T-stop from MIT at the Massachusetts General Hospital (185 Cambridge St, Boston MA 02114).</span><span style="font-family:Helvetica"><o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Contact Name<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica">Christopher E. Carr<o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Contact E-mail<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica"><a href="mailto:chrisc@mit.edu">chrisc@mit.edu</a><o:p></o:p></span></p>
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<span style="font-size:13.0pt;color:#4F81BD">Contact Details:<o:p></o:p></span></h2>
<p class="MsoNormal" style="margin-bottom:10.0pt"><span style="font-family:Helvetica;color:#1A1A1A">Send email with “UROP” in subject line, resume/CV, and short statement of interest by March 6 to
<a href="mailto:chrisc@mit.edu">chrisc@mit.edu</a>.</span><span style="font-family:Helvetica"><o:p></o:p></span></p>
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