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<p class="MsoNormal">Begin forwarded message:<o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-family:"Helvetica Neue"">From: </span></b><span style="font-family:"Helvetica Neue"">Brittany Greenough <<a href="mailto:bgreeno@mit.edu">bgreeno@mit.edu</a>></span><o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-family:"Helvetica Neue"">Subject: [Biograds] Today @ 2:00pm: Aging Brain Seminar Series with Jerold Chun, MD, PhD | Tuesday, November 5 @ 2:00pm</span></b><o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-family:"Helvetica Neue"">Date: </span></b><span style="font-family:"Helvetica Neue"">November 5, 2019 at 10:27:17 AM EST</span><o:p></o:p></p>
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<b><span style="font-size:13.5pt;font-family:"Helvetica Neue";color:#1CA4E3"><a href="https://picowerinstituteatmit.cmail19.com/t/t-i-buijkid-l-p/"><span style="color:#1CA4E3;text-decoration:none">Seminar with Jerold Chun, MD, PhD, Sanford Burnham Prebys Medical
Discovery Institute</span></a><o:p></o:p></span></b></p>
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<p class="MsoNormal"><span style="font-family:"Helvetica Neue""><a href="https://picowerinstituteatmit.cmail19.com/t/t-i-buijkid-l-g/"><span style="color:windowtext;text-decoration:none"><span style="color:blue"><img border="0" width="300" height="198" style="width:3.125in;height:2.0625in" id="_x0000_i1026" src="http://i2.cmail19.com/ei/t/A2/5F6/F55/csimport/Picture1.183924.png"></span></span></a></span><o:p></o:p></p>
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<p class="MsoNormal" style="margin-bottom:11.25pt;line-height:13.5pt"><strong><i><span style="font-size:12.0pt;font-family:"Helvetica Neue";color:#707375">Genomic mosaicism and somatic gene recombination in the normal and Alzheimer’s disease brain</span></i></strong><o:p></o:p></p>
<p class="MsoNormal" style="margin-bottom:11.25pt;line-height:13.5pt"><strong><span style="font-size:10.0pt;font-family:"Helvetica Neue";color:red">Tuesday, November 5th at 2:00 PM</span></strong><o:p></o:p></p>
<p class="MsoNormal" style="margin-bottom:11.25pt;line-height:13.5pt"><span style="font-size:10.0pt;font-family:"Helvetica Neue";color:#707375"><a href="https://picowerinstituteatmit.cmail19.com/t/t-i-buijkid-l-w/"><strong><span style="font-family:"Helvetica Neue";color:red">Room
46-3310 (Picower Seminar Room)</span></strong></a></span><o:p></o:p></p>
<p class="MsoNormal" style="margin-bottom:11.25pt;line-height:13.5pt"><span style="font-size:10.0pt;font-family:"Helvetica Neue";color:#707375">Speculations that somatic DNA sequence changes might underlie the brain’s elaborate cellular diversity and organization
co-emerged in the 1960s with antibody diversity-generating mechanisms that were first demonstrated by S. Tonegawa through V(D)J recombination in the mid-1970s. Efforts to identify an analogous form of gene recombination in the brain that began at MIT in the
late 1980s, were not clarifying. However, these efforts identified genomic mosaicism – wherein each brain cell genome is distinct in its DNA sequence – and indicated that focusing on single or a few cells harboring a mosaically recombined gene might enable
its detection, especially if a candidate existed. Such a candidate emerged in the Alzheimer’s disease gene Amyloid Precursor Protein (APP). Evidence for APP somatic gene recombination (SGR) in human neurons will be presented: SGR is distinct from immunological
recombination and involves reverse transcriptase activity to synthesize “genomic cDNAs” that lack introns, which may represent a more ancient process by analogy to forms of recombination in yeast and evolutionary processed pseudogenes, but occurring somatically
in the human brain. Implications for normal brain function and Alzheimer’s disease will be discussed.</span><o:p></o:p></p>
<p class="MsoNormal" style="margin-bottom:11.25pt;line-height:13.5pt"><em><span style="font-size:10.0pt;font-family:"Helvetica Neue";color:#707375">Jerold Chun, MD, PhD, is Professor and Senior Vice President of Neuroscience Drug Discovery at Sanford Burnham
Prebys Medical Discovery Institute (SBP). He received his MD and PhD degrees (Neuroscience; with C.J. Shatz) through the Medical Scientist Training Program at Stanford University School of Medicine. He moved east as a Helen Hay Whitney Postdoctoral Fellow
to the Whitehead Institute for Biomedical Research, MIT (with R. Jaenisch and D. Baltimore). Dr. Chun then joined the faculty at the UCSD School of Medicine, where he became Professor of Pharmacology and Neurosciences and directed the Neurosciences Graduate
Program. He subsequently became Department Head of Molecular Neuroscience at Merck Research Laboratories before returning to academia as Professor at The Scripps Research Institute and adjunct Professor at UCSD, before his current position. He has made important
contributions to our understanding of the brain and its diseases. His lab identified genomic mosaicism and somatic gene recombination within the brain and its involvement in the most common forms of Alzheimer’s disease, with relevance to other brain diseases.
In separate work, his lab also identified the first lysophospholipid receptor, an initial member of a growing family of lipid receptors that includes S1P receptors that are targets for two current neuroscience medicines (fingolimod & siponimod for Multiple
Sclerosis) with lysophospholipid receptors also linked to other diseases, including hydrocephalus, schizophrenia, neuropathic pain and fibrosis. Dr. Chun has authored more than 300 scientific publications, has been recognized in Thomson Reuters’ World’s Most
Influential Scientific Minds citation list, and is a member of numerous advisory, review, and editorial boards in both academia and industry.</span></em><o:p></o:p></p>
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