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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Chelsea Catania <cataniac@mit.edu><br>
<b>Subject: </b>Tomorrow: Microbiome Club Seminar Prof Alex Kostic 4/23 at 5:30PM<o:p></o:p></span></p>
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<span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">MIT Microbiome Club </span><o:p></o:p></p>
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<span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">Faculty Seminar</span><o:p></o:p></p>
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<img width="150" height="146" style="width:1.5625in;height:1.5208in" id="AA7E706F-4528-4F16-A278-ABE365D66540" src="cid:image001.jpg@01D4F90B.B6C5CD80" alt="cid:DE188664-4E8D-43E8-AA08-7505B7991C01@broadinstitute.org"><o:p></o:p></p>
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<b><span style="font-size:27.0pt;font-family:"Avenir Book";color:#28916B">Prof. Alex Kostic</span></b><o:p></o:p></p>
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<i><span style="font-size:27.0pt;font-family:"Avenir Book";color:#28916B">Performance-Enhancing Bugs: Exercise Physiology Meets the Gut Microbiome</span></i><o:p></o:p></p>
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<span style="font-size:24.0pt;font-family:"Avenir Book";color:#3A3E44">Tuesday, April 23rd at 5:30PM in </span><span style="font-size:24.0pt;font-family:Avenir-Book"><a href="https://whereis.mit.edu/?go=56">56-614</a> </span><o:p></o:p></p>
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<span style="font-size:10.5pt;font-family:Avenir-Book">The human gut microbiome encodes a vast metabolic repertoire, yet it is unknown whether it can impact exercise performance. To begin to address this question, we performed longitudinal metagenomic analysis
on runners in the Boston Marathon to identify microbiome features associated with intense exercise. The strongest microbiome feature enriched post-marathon was an increase in the abundance of the bacterial genus Veillonella. We isolated Veillonella atypica
directly from the marathon runners and found that inoculation in laboratory mice increased exhaustive treadmill runtime by 13% in a V. atypica-dependent manner. Veillonella utilize lactate as their sole carbon source, which prompted us to perform shotgun metagenomic
analysis in a cohort of elite athletes, finding that every gene in a major pathway metabolizing lactate to propionate is at higher relative abundance post-exercise. Using 13C3-labeled lactate in mice we demonstrate that serum lactate crosses the epithelial
barrier into the lumen of the gut. We also show that intrarectal instillation of propionate is sufficient to reproduce the increased treadmill runtime performance observed with V. atypica gavage. Taken together, these studies reveal that V. atypica improves
runtime via its metabolic conversion of exercise-induced lactate into propionate, thereby identifying a natural, microbiome-encoded enzymatic process that enhances athletic performance.</span><span style="font-size:10.5pt;font-family:"Times New Roman",serif"></span><span style="font-size:10.5pt;font-family:Avenir-Book"><br>
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<b>Biography:</b> Professor Kostic's background and training is in computational biology, microbiology, and immunology. During his PhD thesis work with Matthew Meyerson and Wendy Garrett, he discovered an association between colorectal cancer and the gut microbiome
constituent Fusobacterium nucleatum. He demonstrated that Fusobacterium accelerated intestinal tumorigenesis by a mechanism involving altered immune cell recruitment to the tumor, which he established after developing a mouse model with a humanized microbiome.
As a postdoctoral fellow at Broad Institute working with Ramnik Xavier and Curtis Huttenhower, he worked to characterize the developing infant gut microbiome in dense, longitudinal metagenomic analyses of birth cohorts at risk for type 1 diabetes. He discovered
a novel mechanism by which the human microbiome directly influences immune development and progression to type 1 diabetes. In his new lab, he focuses on simplified microbial communities in gnotobiotic mice to discover basic lines of microbiome-host communication
necessary for homeostasis and that underlie autoimmune disease.</span><span style="font-size:10.5pt;font-family:"Times New Roman",serif"></span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-family:"Avenir Book";color:black">______________________________ </span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><i><span style="font-family:"Avenir Book";color:#16191F">The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT
undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine.<a href="https://www.facebook.com/MITmicrobiomeclub/"><span style="color:#16191F"> </span><span style="color:#386EFF">Learn
more on our Facebook page. </span></a>Or follow us on </span></i><span style="color:black"><a href="https://twitter.com/MITubiomeclub"><i><span style="font-family:"Avenir Book"">Twitter</span></i></a></span><i><span style="font-family:"Avenir Book";color:#16191F">. </span></i><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-family:Avenir-Book;color:black">Chelsea Catania, Ph.D.</span></b><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">MIT Microbiome Club President</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Postdoctoral Associate</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Laboratory for Energy and Microsystems Innovation</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Department of Mechanical Engineering</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">@<a href="https://twitter.com/MITubiomeclub">MITubiomeclub</a> </span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="color:black"><a href="http://mailman.mit.edu/mailman/options/microbiome-club"><span style="font-family:Avenir-Book">subscribe</span></a><o:p></o:p></span></p>
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