<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:"Avenir Book";
panose-1:2 0 5 3 2 0 0 2 0 3;}
@font-face
{font-family:Avenir-Book;
panose-1:2 0 5 3 2 0 0 2 0 3;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p.msonormal0, li.msonormal0, div.msonormal0
{mso-style-name:msonormal;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
span.EmailStyle18
{mso-style-type:personal-reply;
font-family:"Calibri",sans-serif;
color:windowtext;
font-weight:normal;
font-style:normal;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-US" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Chelsea Catania <cataniac@mit.edu><br>
<b>Subject: </b>Microbiome Club Seminar: Prof Yang-Yu Liu, Monday 3/18 @ 12 PM in 56-614<o:p></o:p></span></p>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<p class="MsoNormal" align="center" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center">
<span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">MIT Microbiome Club </span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center">
<span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">Faculty Seminar</span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center">
<img width="150" height="146" style="width:1.5625in;height:1.5208in" id="_x0030_3919489-660D-40D4-9729-946DB3F304F0" src="cid:image001.jpg@01D4D9BD.6AE3B020" alt="cid:DE188664-4E8D-43E8-AA08-7505B7991C01@broadinstitute.org"><o:p></o:p></p>
<p class="MsoNormal" align="center" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center">
<b><span style="font-size:27.0pt;font-family:"Avenir Book";color:#28916B">Prof. Yang-Yu Liu</span></b><o:p></o:p></p>
<p class="MsoNormal" align="center" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center">
<i><span style="font-size:27.0pt;font-family:"Avenir Book";color:#28916B">Controlling Human Microbiota</span></i><o:p></o:p></p>
<p class="MsoNormal" align="center" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center">
<span style="font-size:24.0pt;font-family:"Avenir Book";color:#3A3E44">Monday, March 18th at 12PM in </span><a href="https://whereis.mit.edu/?go=56"><span style="font-size:24.0pt;font-family:"Avenir-Book",serif">56-614</span></a><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<b><span style="font-size:10.5pt;font-family:"Avenir-Book",serif">Biography:</span></b><span style="font-size:10.5pt;font-family:"Avenir-Book",serif"> Yang-Yu Liu is currently an Assistant Professor at Harvard Medical School (HMS) and an Associate Scientist
at Brigham and Women’s Hospital (BWH). He received his Ph.D. in Physics from University of Illinois at Urbana-<a name="OLE_LINK3"></a><a name="OLE_LINK4"></a><span style="mso-bookmark:OLE_LINK3"><span style="color:black">Champaign </span></span>in 2009, with
thesis research focusing on phase transitions in disordered magnets. After that, he held positions as Postdoctoral Research Associate and then Research Assistant Professor in the Center for Complex Network Research at Northeastern University, before he joined
HMS and BWH in 2013. The primary goal of his postdoctoral research has been to combine tools from control theory, network science and statistical physics to address fundamental questions pertaining to the control of complex networks. His work on controllability
and observability of complex networks have been featured as a cover story in <i>Nature</i>, a cover story in the <i>PNAS</i>, and received broad media coverage including <i>Nature, Science, Science News, Science Daily, Wired</i>, etc. His current research
efforts focus on the study of human microbiome from the community ecology, dynamic systems and control theory perspectives. His recent work on the universality of human microbial dynamics has been published in <i>Nature</i>, and received broad media coverage
including <i>Nature, Nature Physics</i>, <i>Science Daily, Science News Line, Medical Research, Medical Press, etc</i>. For more information, please visit </span><span style="font-size:10.5pt"><a href="http://scholar.harvard.edu/yyl/"><span style="font-family:"Avenir-Book",serif">http://scholar.harvard.edu/yyl/</span></a></span><o:p></o:p></p>
<div>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Avenir-Book",serif">Abstract:</span></b><span style="font-size:10.5pt;font-family:"Avenir-Book",serif"> We coexist with a vast number of microbes—our microbiota—that live in and on our bodies,
and play an important role in human physiology and diseases. Many scientific advances have been made through the work of large-scale, consortium-driven metagenomic projects. Despite these advances, there are still many fundamental questions regarding the dynamics
and control of microbiota to be addressed. Indeed, it is well established that human-associated microbes form a very complex and dynamic ecosystem, which can be altered by drastic diet change, medical interventions, and many other factors. The alterability
of our microbiome offers opportunities for practical microbiome-based therapies, e.g., fecal microbiota transplantation and probiotic administration, to restore or maintain our healthy microbiota. Yet, the complex structure and dynamics of the underlying ecosystem
render the quantitative study of microbiome-based therapies extremely difficult. In this talk, I will discuss our recent theoretical progress on controlling human microbiota f<a name="OLE_LINK2"><span style="color:black">rom dynamical systems and control theory
perspectives</span></a> [1-4].</span><o:p></o:p></p>
</div>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-right:.7pt;mso-margin-bottom-alt:auto;text-align:justify">
<b><span style="font-size:10.5pt;font-family:"Avenir-Book",serif">References:</span></b><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-right:.7pt;mso-margin-bottom-alt:auto;text-align:justify">
<span style="font-size:10.5pt;font-family:"Avenir-Book",serif">[1] Bashan A, Gibson TE, Friedman J, Carey VJ, Weiss ST, Hohmann EL, Liu Y-Y. <i>Universality of Human Microbial Dynamics.</i>Nature 2016;534:259-262</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-right:.7pt;mso-margin-bottom-alt:auto;text-align:justify">
<span style="font-size:10.5pt;font-family:"Avenir-Book",serif">[2] Gibson TE, Bashan A, Cao H-T, Weiss ST, Liu Y-Y.<i>On the Origins and Control of Community Types in the Human Microbiome. </i>PLoS Computational Biology 2016;12(2):e1004688.</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-right:.7pt;mso-margin-bottom-alt:auto;text-align:justify">
<span style="font-size:10.5pt;font-family:"Avenir-Book",serif">[3] Xiao Y, Angulo MT, Friedman J, Waldor MK, Weiss ST, Liu Y-Y. <i>Mapping the ecological networks of microbial communities. </i>Nature Communications 2017;8:2042.</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-right:.7pt;mso-margin-bottom-alt:auto;text-align:justify">
<span style="font-size:10.5pt;font-family:"Avenir-Book",serif">[4] Angulo MT, Moog CH, Liu Y-Y.<i>A Theoretical framework of controlling microbial communities. </i>Nature Communications 2019;10:1045</span><o:p></o:p></p>
<div>
<div>
<div>
<div>
<div>
<div>
<div>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-family:"Avenir Book";color:black">______________________________ </span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><i><span style="font-family:"Avenir Book";color:#16191F">The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT
undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine.<a href="https://www.facebook.com/MITmicrobiomeclub/"><span style="color:#16191F"> </span><span style="color:#386EFF">Learn
more on our Facebook page. </span></a>Or follow us on </span></i><span style="color:black"><a href="https://twitter.com/MITubiomeclub"><i><span style="font-family:"Avenir Book"">Twitter</span></i></a></span><i><span style="font-family:"Avenir Book";color:#16191F">. </span></i><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
</div>
<div>
<p class="MsoNormal"><b><span style="font-family:"Avenir-Book",serif;color:black">Chelsea Catania, Ph.D.</span></b><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">MIT Microbiome Club President</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">Postdoctoral Associate</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">Laboratory for Energy and Microsystems Innovation</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">Department of Mechanical Engineering</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">@<a href="https://twitter.com/MITubiomeclub">MITubiomeclub</a> </span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
<p class="MsoNormal"><br>
<br>
<o:p></o:p></p>
</div>
</body>
</html>