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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Chelsea Catania <cataniac@mit.edu><br>
<b>Date: </b>Tuesday, October 30, 2018 at 10:51 AM<br>
<b>To: </b>microbiome-club <microbiome-club@mit.edu><br>
<b>Subject: </b>CORRECTION: Microbiome Club Faculty Seminar: Prof. Michelle O'Malley, 11/6 at 12:30 PM in 56-614<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif">Correction: TUESDAY, sorry!</span><o:p></o:p></p>
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<span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">MIT Microbiome Club </span><o:p></o:p></p>
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<span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">Faculty Seminar Series</span><o:p></o:p></p>
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<img width="150" height="146" style="width:1.5625in;height:1.5208in" id="_x0035_D6A5038-8847-46F0-A6E1-7E4EECD2D7D2" src="cid:image001.jpg@01D4703E.914812D0" alt="cid:DE188664-4E8D-43E8-AA08-7505B7991C01@broadinstitute.org"><o:p></o:p></p>
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<b><span style="font-size:27.0pt;font-family:"Avenir Book";color:#28916B">Prof. Michelle O'Malley</span></b><o:p></o:p></p>
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<i><span style="font-size:27.0pt;font-family:"Avenir Book";color:#28916B">Engineering Synthetic Microbial Consortia Inspired by the Herbivore Rumen</span></i><o:p></o:p></p>
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<span style="font-size:24.0pt;font-family:"Avenir Book";color:#3A3E44">TUESDAY, November 6th at 12:30 PM in 56-614 (<a href="https://www.facebook.com/events/1311485768987773/">RSVP</a>)</span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:13.5pt;font-family:"Avenir-Book",serif">Come early for pizza!</span><o:p></o:p></p>
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<span style="font-family:"Avenir-Book",serif">Anaerobic microbes evolved to work together in complex communities that decompose and recycle carbon biomass throughout the Earth – from our guts to landfills and compost piles. Despite their importance, little
information exists to parse the role of each microbial member within their dynamic community. To address these knowledge gaps, we pioneered new techniques to isolate anaerobes from biomass-rich environments (e.g. guts and fecal materials of herbivores) and
build synthetic consortia to uncover their interdependencies. Initially, we tracked the development of enrichment cultures from goat fecal pellets grown on four types of substrates: alfalfa stem, bagasse, reed canary grass, and xylan over several generations.
We tested the hypothesis that the composition of these enriched consortia would stabilize to match the metabolic requirements needed to degrade each substrate. Metagenomic sequencing of the 16S rRNA (prokaryotes), 18S rRNA (eukaryotes), and ITS (fungi) population
within the consortia revealed strong specialization of the microbes during selection, suggesting that the membership of each culture tuned to match the substrate. Using these natural systems as inspiration, synthetic consortia of fungi, bacteria, and methanogens
were combined in culture and tested for stability and substrate hydrolysis. In nearly all cases, synthetic consortia demonstrated faster and more complete degradation of cellulosic substrates, as well as a wider range of utilized substrates compared to monocultures.
We will further discuss the roles that interwoven metabolism and secondary metabolites play on microbial consortia dynamics, both in natural and synthetic systems. Overall, the stable microbial consortia we identified here directed the formation of synthetic,
interdependent communities via a bottom up approach to compartmentalize biomass-degradation and bioproduct formation.</span><o:p></o:p></p>
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<img border="0" width="320" height="240" style="width:3.3333in;height:2.5in" id="DD4EE0BC-6AB4-4782-A1AD-53B915A9EB00" src="cid:image002.jpg@01D4703E.914812D0" alt="cid:024C3A15-59C7-446A-BCA0-AF58E3BB3EAC@mit.edu"><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span style="font-family:"Avenir-Book",serif">Bio:</span></b><span style="font-family:"Avenir-Book",serif"> Michelle A. O’Malley earned a B.S. in Chemical Engineering and Biomedical
Engineering from Carnegie Mellon University in 2004. She holds a PhD in Chemical Engineering from the University of Delaware in 2009, where she worked with Prof. Anne Robinson to engineer overproduction of membrane proteins in yeast. O’Malley was a USDA-NIFA
postdoctoral fellow in the Department of Biology at MIT, where she developed new strategies for cellulosic biofuel production. She joined the Chemical Engineering faculty at UC-Santa Barbara in 2012, and her research group engineers protein synthesis within
anaerobes and consortia for sustainable chemical production, bioremediation, and natural product discovery. O’Malley’s research has been featured on NPR’s <i>Science Friday</i>, the <i>BBC Newshour</i>, the <i>LA Times</i>, and several other media outlets.
She was named one of the 35 Top Innovators Under 35 in the world by <i>MIT Technology Review</i> in 2015, and is the recipient of the Presidential Early Career Award for Scientists and Engineers (PECASE), a DOE Early Career Award, an NSF CAREER award, the
Camille Dreyfus Teacher-Scholar Award, an ACS PMSE Young Investigator Award, an ACS WCC “Rising Star” Award, and a Hellman Faculty Fellowship.</span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-family:"Avenir Book";color:black">______________________________ </span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><i><span style="font-family:"Avenir Book";color:#16191F">The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT
undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine.<a href="https://www.facebook.com/MITmicrobiomeclub/"><span style="color:#16191F"> </span><span style="color:#386EFF">Learn
more on our Facebook page. </span></a>Or follow us on </span></i><span style="color:black"><a href="https://twitter.com/MITubiomeclub"><i><span style="font-family:"Avenir Book"">Twitter</span></i></a></span><i><span style="font-family:"Avenir Book";color:#16191F">. </span></i><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-family:"Avenir-Book",serif;color:black">Chelsea Catania, Ph.D.</span></b><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">MIT Microbiome Club President</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">Postdoctoral Associate</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">Laboratory for Energy and Microsystems Innovation</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">Department of Mechanical Engineering</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Avenir-Book",serif;color:black">@<a href="https://twitter.com/MITubiomeclub">MITubiomeclub</a> </span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="color:black"><a href="http://mailman.mit.edu/mailman/options/microbiome-club"><span style="font-family:"Avenir-Book",serif">Unsubscribe</span></a><o:p></o:p></span></p>
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