<html xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
{font-family:Helvetica;
panose-1:0 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p.msonormal0, li.msonormal0, div.msonormal0
{mso-style-name:msonormal;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
p.xmsonormal, li.xmsonormal, div.xmsonormal
{mso-style-name:x_msonormal;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
p.xmsolistparagraph, li.xmsolistparagraph, div.xmsolistparagraph
{mso-style-name:x_msolistparagraph;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
span.EmailStyle20
{mso-style-type:personal-reply;
font-family:"Calibri",sans-serif;
color:windowtext;
font-weight:normal;
font-style:normal;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style>
</head>
<body lang="EN-US" link="blue" vlink="purple">
<div class="WordSection1">
<p class="xmsonormal"><b>Term: </b>Fall & Spring<o:p></o:p></p>
<p class="xmsonormal"><b>UROP Department, Lab or Center: </b>Koch Institute for Cancer Research, Biology (Course 7)<o:p></o:p></p>
<p class="xmsonormal"><b>MIT Faculty Supervisor Name</b>: Michael Hemann<o:p></o:p></p>
<p class="xmsonormal"><b>Project Title: </b> Identification of a microenvironmental factor mediating gemcitabine resistance in pancreatic cancer<o:p></o:p></p>
<p class="xmsonormal"><b>Project Description: </b> <o:p></o:p></p>
<p class="xmsonormal">Although pancreatic ductal adenocarcinoma (PDAC) is only the 11<sup>th</sup> most common cancer, it is the 3<sup>rd</sup> leading cause of cancer deaths in the United States. Unfortunately, most patients treated with one of the front-line
chemotherapies, gemcitabine, develop resistance to this drug. We have identified a factor that is secreted by non-tumor cells which reduces gemcitabine’s potency in tumor cells. We are now working to understand why this factor is being produced and how it
prevents gemcitabine toxicity. <o:p></o:p></p>
<p class="xmsonormal">The Hemann lab is looking for a student who is interested in cancer research and studying chemotherapy resistance to assist with this project. This opportunity is offered for the Fall and Spring terms with possibility for continuation
during next summer. The student will learn a variety of techniques including mammalian cell culture, drug sensitivity and cell viability assays and various types of biochemical extractions.<o:p></o:p></p>
<p class="xmsonormal">If interested, please send your CV/resume and detail any experience or course work you have had with molecular biology and experimental biology.<o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:7.0pt;font-family:"Times New Roman",serif"> </span>Academic year 2018/2019<o:p></o:p></p>
<p class="xmsolistparagraph" style="text-indent:-.25in"><span style="font-family:Symbol">·</span><span style="font-size:7.0pt;font-family:"Times New Roman",serif"> </span>Direct Supervisor: Simona Dalin<o:p></o:p></p>
<p class="xmsonormal"> <b>Prerequisites:</b><o:p></o:p></p>
<p class="xmsolistparagraph" style="text-indent:-.25in"><span style="font-family:Symbol">·</span><span style="font-size:7.0pt;font-family:"Times New Roman",serif"> </span>Cell culture experience<o:p></o:p></p>
<p class="xmsolistparagraph" style="text-indent:-.25in"><span style="font-family:Symbol">·</span><span style="font-size:7.0pt;font-family:"Times New Roman",serif"> </span>Good communication and organizational skills<o:p></o:p></p>
<p class="xmsolistparagraph" style="text-indent:-.25in"><span style="font-family:Symbol">·</span><span style="font-size:7.0pt;font-family:"Times New Roman",serif"> </span>Strong background in experimental and molecular biology<o:p></o:p></p>
<p class="xmsolistparagraph" style="text-indent:-.25in"><span style="font-family:Symbol">·</span><span style="font-size:7.0pt;font-family:"Times New Roman",serif"> </span>Interest in pursuing a graduate degree in the life sciences is considered a plus<o:p></o:p></p>
<p class="xmsonormal"> <b>Contact:</b> Simona Dalin (<a href="mailto:sdalin@mit.edu">sdalin@mit.edu</a>)<o:p></o:p></p>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
<div>
<p class="MsoNormal">Begin forwarded message:<o:p></o:p></p>
</div>
<p class="MsoNormal"><br>
<br>
<o:p></o:p></p>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<div>
<p class="MsoNormal"><b><span style="font-family:Helvetica">From: </span></b><span style="font-family:Helvetica">Simona Dalin <<a href="mailto:sdalin@mit.edu">sdalin@mit.edu</a>></span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><b><span style="font-family:Helvetica">Subject: Looking for a UROP student</span></b><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><b><span style="font-family:Helvetica">Date: </span></b><span style="font-family:Helvetica">July 9, 2018 at 6:05:02 PM EDT</span><o:p></o:p></p>
</div>
</blockquote>
<p class="MsoNormal"><br>
<br>
<o:p></o:p></p>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<div>
<p class="MsoNormal">I am looking for a UROP student for the coming school year. I have attached a description of the project to this email. If you hear from any undergrads interested in doing a UROP studying chemotherapy resistance and learning cell culture
assays, please let me know!<o:p></o:p></p>
</div>
<div>
<div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal">Thank you,<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">Simona<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><br clear="all">
<br>
-- <o:p></o:p></p>
<div>
<div>
<div>
<div>
<div>
<div>
<div>
<div>
<p class="MsoNormal">Simona Dalin<o:p></o:p></p>
</div>
<p class="MsoNormal">PhD Candidate, Hemann & Lauffenburger Labs<o:p></o:p></p>
</div>
<p class="MsoNormal">Department of Biology<br>
Massachusetts Institute of Technology<o:p></o:p></p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</blockquote>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
</div>
</body>
</html>