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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri">Please see the information below about the Advanced Undergraduate Seminar 7.344: "Metabolism and Human Disease." This class is still open.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri">Best,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri">Crystal<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">---------------</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Crystal Boateng (Pronouns: they/them/themselves)</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Biology Education Office 68-120<br>
Massachusetts Institute of Technology<br>
31 Ames Street, Cambridge, MA 02139</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">ph: 617-252-1783 / f: 617-258-9329 / e: </span><span style="color:black"><a href="mailto:cboateng@mit.edu"><span style="font-size:9.0pt;font-family:Helvetica">cboateng@mit.edu</span></a><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-family:Calibri;color:black">From: </span>
</b><span style="font-family:Calibri;color:black">Allison Lau <anlau@mit.edu><o:p></o:p></span></p>
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<b><span style="font-size:14.0pt;color:black">7.344 Metabolism and Human Disease</span></b><span style="font-size:14.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal" style="margin-left:.5in"><b><span style="font-size:10.0pt;font-family:Tahoma;color:black">The class time for this seminar has been changed to
</span></b><b><span style="font-family:Tahoma;color:black">MONDAY, 2-4 PM</span></b><b><span style="font-size:10.0pt;font-family:Tahoma;color:black">, located in 76-558. If you missed the first class, you can still take this course- registration is still open!
Please email the instructors if interested. Thank you!</span></b><span style="font-size:10.0pt;font-family:Tahoma;color:black"><o:p></o:p></span></p>
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<span style="color:black"><a href="http://stellar.mit.edu/S/course/7/fa16/7.344/" target="_blank"><span style="font-size:10.0pt">http://stellar.mit.edu/S/course/7/fa16/7.344/</span></a><o:p></o:p></span></p>
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<span style="color:black">Instructors: Allison Lau (<a href="mailto:lewisca@mit.edu">anlau@mit.edu</a>, 5-4523; laboratory of Matthew Vander Heiden)<o:p></o:p></span></p>
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<span style="color:black"> Alexander Muir (<a href="mailto:amuir@mit.edu">amuir@mit.edu</a>, 5-4523; laboratory of Matthew Vander Heiden)<o:p></o:p></span></p>
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<span style="color:black">Cancer and diabetes are the 2<sup>nd</sup> and 7<sup>th</sup> leading causes of death in the United States, with diabetes also being a major risk factor for other deadly conditions, such as cardiovascular disease. The incidence rates
for both diabetes and cancer are increasing, and together cancer and diabetes will kill more than half a million U.S. residents this year. It is pressing to understand, prevent and treat these increasingly prevalent diseases. Underpinning both cancer and diabetes
are dramatic changes in metabolism, the basic energy and mass-producing biochemical reactions of the cell. In this course, we will explore how metabolic alterations drive cancer and diabetes. We will ask questions such as: Why do tumors consume more sugar
than normal cells? How does a drug used to treat diabetes also decrease cancer incidence and death? How does the liver store excess sugar after a meal, and how do metabolic changes in diabetics alter this liver function? How do fat cells know when to store
or burn fuels? We will read, discuss and critically evaluate primary scientific papers about these topics to learn how scientists experimentally approach fundamental issues in biology and medicine. We will see that recent findings have challenged the traditional
“textbook” understanding of metabolism and given us new insight into cancer and diabetes. For example, we will discuss the surprising finding that isocitrate dehydrogenase (IDH), a well characterized metabolic enzyme previously thought to simply function in
the energy producing TCA cycle, can become mutated to become a potent oncogene by producing a novel cancer-causing metabolite. Students will have the opportunity to visit a local pharmaceutical company that is developing therapeutics to target cancer metabolism,
including inhibitors of mutant IDH proteins, in an effort to revolutionize cancer therapy.</span><span style="font-size:10.0pt;font-family:Tahoma;color:black">
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