<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:x="urn:schemas-microsoft-com:office:excel" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Title" content="">
<meta name="Keywords" content="">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<style id="owaParaStyle"><!--
/* Font Definitions */
@font-face
{font-family:"ＭＳ 明朝";}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p
{mso-style-priority:99;
margin:0in;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman";}
p.msochpdefault, li.msochpdefault, div.msochpdefault
{mso-style-name:msochpdefault;
margin:0in;
margin-bottom:.0001pt;
font-size:10.0pt;
font-family:"Times New Roman";}
span.emailstyle20
{mso-style-name:emailstyle20;
font-family:Calibri;
color:windowtext;}
span.msoins
{mso-style-name:msoins;
color:teal;
text-decoration:underline;}
span.emailstyle22
{mso-style-name:emailstyle22;
font-family:Calibri;
color:windowtext;}
span.EmailStyle23
{mso-style-type:personal-reply;
font-family:Calibri;
color:windowtext;}
span.msoIns
{mso-style-type:export-only;
mso-style-name:"";
text-decoration:underline;
color:teal;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style>
</head>
<body bgcolor="white" lang="EN-US" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri">Please see the information below about the Advanced Undergraduate Seminar 7.346: "Hunting for the Genes that Cause Brain Disorders and Aging." This class is still open.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri">Thanks,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri">Crystal<o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">---------------</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Crystal Boateng (Pronouns: they/them/themselves)</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Biology Education Office 68-120<br>
Massachusetts Institute of Technology<br>
31 Ames Street, Cambridge, MA 02139</span><span style="color:black"><o:p></o:p></span></p>
</div>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">ph: 617-252-1783 / f: 617-258-9329 / e: </span><span style="color:black"><a href="mailto:cboateng@mit.edu"><span style="font-size:9.0pt;font-family:Helvetica">cboateng@mit.edu</span></a></span><span style="font-size:11.0pt;font-family:Calibri"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri"><o:p> </o:p></span></p>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-family:Calibri;color:black">From: </span>
</b><span style="font-family:Calibri;color:black">Zara Herskovits <aherskov@mit.edu><o:p></o:p></span></p>
</div>
<div>
<div>
<div>
<div>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:Tahoma;color:black"><br>
<strong><span style="font-family:Tahoma">Biology 7.346 "Hunting for the Genes that Cause Brain Disorders and Aging"
</span></strong></span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p><span style="font-size:10.0pt;font-family:Tahoma;color:black">Neurological diseases are one of the most important medical challenges facing society today. One in four people will have an episode of major depression in their lifetimes, and almost half of
people over 85 years old have Alzheimer's disease. This course will walk through how the first genes for monogenic neurodegenerative disorders, such as amyotrophic lateral sclerosis and Huntington's disease, were discovered using classical approaches. We
will continue through current studies, from which the genetic architecture of complex diseases such as schizophrenia are just being uncovered. We will discuss how an individual's risk of developing a disease can be assessed from small genetic changes in nucleotide
sequence and on larger structural variations that affect entire regions of a chromosome. We will read papers from the primary scinetific literature to understand how genetics is informing the treatment of patients with neurological disorders. Genomic anlaysis
has spurred the development of new treatment strategies, such as antisense oligonucleotide therapies for diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis. This course will combine discussions of primary scientific literature with
hands-on data analysis and small group presentations. We will take a field trip to a local pharmaceutical company to learn about how new treatments for these neurological conditions are being developed.<o:p></o:p></span></p>
<p><span style="font-size:10.0pt;font-family:Tahoma;color:black"><o:p> </o:p></span></p>
<p><span style="font-size:10.0pt;font-family:Tahoma;color:black"><a href="https://stellar.mit.edu/S/course/7/fa16/7.346/" target="_blank">https://stellar.mit.edu/S/course/7/fa16/7.346/</a> <o:p></o:p></span></p>
<p><span style="font-size:10.0pt;font-family:Tahoma;color:black"><o:p> </o:p></span></p>
<p><strong><span style="font-size:10.0pt;font-family:Tahoma;color:black">IF YOU HAVE MISSED THE FIRST CLASS, BUT ARE STILL INTERESTED IN TAKING THIS COURSE, PLEASE EMAIL THE INSTRUCTORS (</span></strong><span style="font-size:10.0pt;font-family:Tahoma;color:black">
<a href="mailto:GLORIOSO@MIT.EDU" target="_blank"><strong><span style="font-family:Tahoma">GLORIOSO@MIT.EDU</span></strong>
</a><strong><span style="font-family:Tahoma">OR</span></strong> <a href="mailto:AHERSKOV@MIT.EDU" target="_blank">
<strong><span style="font-family:Tahoma">AHERSKOV@MIT.EDU</span></strong> </a><strong><span style="font-family:Tahoma">) WITH YOUR PREFERENCES ABOUT MEETING DAY AND TIME AS SOON AS POSSIBLE. REGISTRATION IS STILL OPEN. THANK YOU!</span></strong><o:p></o:p></span></p>
</div>
</div>
</div>
</div>
</div>
</body>
</html>