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<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><b><span style="font-size:12.0pt;font-family:
"Times New Roman";mso-fareast-font-family:"Times New Roman"">Term</span></b><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman"">:
Fall 2015<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><b><span style="font-size:12.0pt;font-family:
"Times New Roman";mso-fareast-font-family:"Times New Roman"">MIT Faculty Supervisor Name</span></b><span style="font-size:12.0pt;font-family:"Times New Roman";
mso-fareast-font-family:"Times New Roman"">:
Dr. Alan Grodzinsky<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><b><span style="font-size:12.0pt;font-family:
"Times New Roman";mso-fareast-font-family:"Times New Roman"">MIT Faculty Supervisor Email</span></b><span style="font-size:12.0pt;font-family:"Times New Roman";
mso-fareast-font-family:"Times New Roman"">:
<a href="mailto:alg@mit.edu">alg@mit.edu</a><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman""> </span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><b><span style="font-size:12.0pt;font-family:
"Times New Roman";mso-fareast-font-family:"Times New Roman"">Project Title</span></b><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman"">:
Evaluation of nanoparticles for drug delivery to cartilage<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman""> </span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><b><span style="font-size:12.0pt;font-family:
"Times New Roman";mso-fareast-font-family:"Times New Roman"">Project Description</span></b><span style="font-size:12.0pt;font-family:"Times New Roman";
mso-fareast-font-family:"Times New Roman"">:
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman"">Osteoarthritis (OA) is the most common form of arthritis, affecting millions
of people worldwide. The biggest challenge to treating OA is that cartilage (the affected tissue) does not have a blood supply, making it impossible to deliver drugs through intravenous or oral administration. Attempts have been made to administer drugs locally
by injecting them into the joint space; but it has been found that these are rapidly cleared by the lymphatic system. Due to this large and frequent doses are required, which in turn can lead to adverse systemic side-effects.
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman""> </span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman"">Our lab is working in collaboration with the Hammond lab to develop polymeric
nanoparticle carriers for drug delivery to the cartilage. The goal is to develop a system that will make the drug available to the cartilage at low doses for long periods of time without being cleared away by the lymphatics. In this specific project, a UROP
will be working with a graduate student to study the uptake and transport properties of different nanoparticles in cartilage. For the nanoparticles that show sufficient uptake, in-vitro toxicity tests will be conducted. The techniques that will be used include
harvesting primary cartilage cells, spectrofluorometry, diffusivity measurement, cell culture techniques, fluorescence microscopy, and possibly confocal microscopy. No prior experience in any of these techniques is necessary. This is an interdisciplinary project
and we invite undergraduates from a wide variety of disciplines including, but not restricted to, Chemical Engineering, Biological Engineering, Biology, Mechanical Engineering and Materials Science and Engineering.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman""> </span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><b><span style="font-size:12.0pt;font-family:
"Times New Roman";mso-fareast-font-family:"Times New Roman"">Contact Name</span></b><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman"">:
Yamini Krishnan<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; "><b><span style="font-size:12.0pt;font-family:
"Times New Roman";mso-fareast-font-family:"Times New Roman"">Contact Email</span></b><span style="font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family:
"Times New Roman"">:<a href="mailto:yamini_k@mit.edu">yamini_k@mit.edu</a><o:p></o:p></span></p>
<!--EndFragment-->
<div><span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px; ">
<div>Joyce Roberge<br>
Undergraduate Program<br>
Biology Education Office 68-120<br>
Massachusetts Institute of Technology<br>
31 Ames Street<br>
Cambridge, MA 02139<br>
617-253-4718<br>
fax: 617-258-9329<br>
email: <a href="mailto:roberge@mit.edu">roberge@mit.edu</a></div>
<div><br>
</div>
</span><br class="Apple-interchange-newline">
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