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<h1><span style="font-size:10.0pt">Research Associate, Cell Biology</span></h1>
<p class="x_MsoNormal"><span style="font-family:Arial; font-size:10pt">Syros Pharmaceuticals is seeking a cellular biologist to join a team of highly motivated scientists that are using recent fundamental insights into transcriptional regulation to discover
novel small molecules for the treatment of cancer.</span></p>
<p class="x_MsoNormal"><span class="x_printverysmall1"><span style="font-size:10.0pt; font-family:Arial"> </span></span></p>
<p class="x_MsoNormal"><span class="x_printverysmall1"><span style="font-size:10.0pt; font-family:Arial">We are an innovative drug discovery company focused on discovering and developing medicines targeting gene control with a focus on the treatment of cancer
and related conditions. Syros was founded in 2012 by leading scientists from the Whitehead Institute and the Dana Farber Cancer Institute with support from top venture firms and a world class Scientific Advisory Board. Combining new insights into enhancer
function with information from genome-wide profiling, we are pursuing new targets and chemical approaches in an effort to unlock the process of gene control for drug discovery.</span></span></p>
<p class="x_MsoNormal"><span class="x_printverysmall1"><span style="font-size:10.0pt; font-family:Arial"> </span></span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">The candidate must have 2+ years of research experience in academia or industry in cell and molecular biology. Proficiency in in standard molecular biology practices including plasmid
cloning and transfection, DNA and protein separation, immuno-blotting, RT-PCR, qPCR, and RNAi techniques is a plus.
</span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial"> </span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Responsibilities:</span></p>
<ul type="disc" style="margin-top:0in">
<li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Performance of cellular assays in support of small molecule drug discovery efforts</span>
</li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Experience in or interest in learning medium to high throughput assays and automation</span>
</li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Simultaneous maintenance and expansion of multiple human cell lines</span>
</li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">RNA purification for expression studies
</span></li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Execution of overexpression and knockdown (shRNA/siRNA) experiments</span>
</li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Performance of protein enrichment (IP) and ChIP-Seq experiments</span>
</li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Interpretation of biological experiments and data visualization</span>
</li></ul>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial"> </span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Requirements:</span></p>
<ul type="disc" style="margin-top:0in">
<li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">BA/BS degree in Cell Biology, molecular biology or related field Basic molecular biology skills: DNA and RNA isolation, PCR, molecular cloning, protein isolation and immune detection</span>
</li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Experience with cell viability assays and cell imaging techniques</span>
</li><li class="x_MsoNormal"><span class="x_printverysmall1"><span style="font-size:10.0pt; font-family:Arial">Strong attention to detail and the ability to handle multiple tasks</span></span>
</li><li class="x_MsoNormal"><span class="x_printverysmall1"><span style="font-size:10.0pt; font-family:Arial">Desire and ability to work in a fast paced, cross-functional, flexible and team-oriented environment</span></span>
</li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Strong interpersonal skills</span>
</li><li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Strong verbal and written communications skills</span>
</li></ul>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial"> </span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Additional skills (optional yet preferred):</span></p>
<ul type="disc" style="margin-top:0in">
<li class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">2+ years of experience in mammalian tissue culture</span>
</li></ul>
<p class="x_MsoListParagraphCxSpFirst" style="text-indent:-.25in"><span style="font-size:10.0pt; font-family:Symbol">·<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:10.0pt; font-family:Arial">Design, cloning, and mutation of protein expression constructs</span></p>
<p class="x_MsoListParagraphCxSpMiddle" style="text-indent:-.25in"><span style="font-size:10.0pt; font-family:Symbol">·<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:10.0pt; font-family:Arial">Familiarity with medium to high throughput biochemical and cellular assays</span></p>
<p class="x_MsoListParagraphCxSpMiddle" style="text-indent:-.25in"><span style="font-size:10.0pt; font-family:Symbol">·<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:10.0pt; font-family:Arial">Utilization of biophysical experimental methods including SPR, ITC, mass spectrometry, or similar methods</span></p>
<p class="x_MsoListParagraphCxSpLast" style="text-indent:-.25in"><span style="font-size:10.0pt; font-family:Symbol">·<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:10.0pt; font-family:Arial">Use of molecular modeling/visualization, protein homology/sequence analyses, or similar computational tools</span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial"> </span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Candidates who are keen experimentalists, enthusiastic team players that have a passion for drug discovery are encouraged to apply. Knowledge of cancer biology and transcriptional regulation
is a plus.</span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial"> </span></p>
<p class="x_MsoNormal"><span style="font-size:10.0pt; font-family:Arial">Interested candidates should respond with their CV to:
<a href="mailto:careers@syros.com">careers@syros.com</a></span></p>
<p class="x_MsoNormal"><span style="font-family:Atlanta; text-align:center">480 Arsenal St. | Suite 130 | Watertown, MA | 02472 | tel. 617.744.1340 | fax 617.744.1377</span></p>
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<div><span class="x_Apple-style-span" style="border-collapse:separate; border-spacing:0px">
<div>Joyce Roberge<br>
Undergraduate Program<br>
Biology Education Office 68-120<br>
Massachusetts Institute of Technology<br>
31 Ames Street<br>
Cambridge, MA 02139<br>
617-253-4718<br>
fax: 617-258-9329<br>
email: <a href="mailto:roberge@mit.edu">roberge@mit.edu</a></div>
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