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<span style="font-family:'Helvetica'"><b>Subject: </b></span><span style="font-family:'Helvetica'"><b>IAP Research Position at Takeda Pharmaceuticals</b><br>
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<span style="font-family:'Helvetica'"><b>Date: </b></span><span style="font-family:'Helvetica'">November 25, 2014 at 2:25:17 AM EST<br>
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<p class="x_MsoNormal" style="margin:0in 0in 12pt; font-size:12pt"><b><font face="arial, helvetica, sans-serif">Do you aspire to solve problems in cancer?<br>
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Interested in computational biology research and exploring industry?</font></b><font face="Times New Roman, serif"><u></u><u></u></font></p>
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<p class="x_MsoNormal" style="margin-bottom:0.0001pt"><span style="font-size:12pt">The Modeling and Simulation group at Takeda Pharmaceuticals in Cambridge, MA is looking for Research Affiliates to work on modeling projects investigating evolution in tumors
and its impact on treatment success.</span></p>
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<p class="x_MsoNormal" style="margin-bottom:0.0001pt"><b><span style="font-size:12pt">Who we are</span></b></p>
<p class="x_MsoNormal" style="margin-bottom:0.0001pt"><span style="font-size:12pt">We are a fast-moving group whose mission is to support rational quantitative decision-making in drug discovery and development through the application of mathematical modeling.
In particular, we identify ways to translate preclinical data into recommendations for clinical development, and to make drugs more developable at every step along the way. We take a forward-thinking approach and build novel capabilities through focused research
projects applying mathematical modeling to drug development in new ways.</span></p>
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<p class="x_MsoNormal" style="margin-bottom:0.0001pt"><b><span style="font-size:12pt">What you will do</span></b></p>
<p class="x_MsoNormal"><span style="font-size:12pt">As a research affiliate, you will work on an independent project in theoretical cancer biology. Working closely with our scientists, you will explore in-depth an industry-relevant basic science question with
the goal of producing your own academic publication. This opportunity will give you research experience in support of a career in scientific positions in academia or industry.</span></p>
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<p class="x_MsoNormal"><span style="font-size:12pt">Potential projects will involve using modeling and simulation to investigate the evolutionary process in tumors including the impact of tumor heterogeneity on disease progression, and how treatment affects
the evolutionary dynamics of a cancer. Projects are expected to take a total of 150 hours to complete, and you should plan on committing at least 20 hours per week during January followed by 8-10 hours per week from February through March. All work is theoretical
or computational, and does not require any wet-lab components.</span><span style="font-size:12pt"></span></p>
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<p class="x_MsoNormal" style="margin-bottom:0.0001pt"><b><span style="font-size:12pt">Who you are</span></b></p>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Current graduate or undergraduate student, or post-doc. All majors and years welcome.</span></div>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Experience with mathematical modeling, differential equations, and statistics.</span></div>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Proficiency with MATLAB, Mathematica, R, Python, or similar.</span></div>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Exposure to evolutionary dynamics and/or game theory is a plus.</span></div>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Comfortable with reading and analyzing scientific literature.</span></div>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Experience with publications is a plus.</span></div>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Organized, with an ability to prioritize time-sensitive assignments.</span></div>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Motivation and creativity to solve problems in cancer biology.</span></div>
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<p class="x_MsoNormal" style="margin-bottom:0.0001pt"><b><span style="font-size:12pt">Details</span></b></p>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">$17/hr (20 hours per week during January 2015, followed by 8-10 hours per week through March 2015 for approximately 150 hours total.)</span></div>
<div style="margin:0in 0in 0.0001pt 0.25in"><span style="font-size:12pt; font-family:Symbol">�<span style="font-size:7pt; font-family:'Times New Roman'">
</span></span><span style="font-size:12pt">Publication expected (minimally, an abstract at an international conference; potential for publication in a peer-reviewed journal.)</span></div>
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<p class="x_MsoNormal" style="margin-bottom:0.0001pt"><b><span style="font-size:12pt">How to Apply</span></b></p>
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<p class="x_MsoNormal" style="margin-bottom:0.0001pt"><span style="font-size:12pt">Contact
</span><a href="mailto:Christopher.Zopf@takeda.com"><span style="font-size:12pt">Christopher.Zopf@takeda.com</span></a><span style="font-size:12pt"> with your resume by December 3, 2014. </span></p>
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