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<p class="MsoNormal"><font class="Apple-style-span" face="Calibri" size="4"><span class="Apple-style-span" style="line-height: 18px;">Please contact </span></font><span style="font-size: 12pt; line-height: 18px; font-family: Calibri; ">Tuomas Tammela (</span><a href="mailto:ttammela@mit.edu"><span style="font-size: 12pt; line-height: 18px; font-family: Calibri; ">ttammela@mit.edu</span></a><span style="font-size: 12pt; line-height: 18px; font-family: Calibri; ">)
if you are interested in applying for this position.</span></p>
<div><br>
</div>
<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:
Calibri;mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin">****************</span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:
Calibri;mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin">Department: Biology/Koch Institute<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:
Calibri;mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin">Faculty Supervisor: Tyler Jacks<o:p></o:p></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:115%;font-family:Calibri;mso-ascii-theme-font:
major-latin;mso-hansi-theme-font:major-latin">Project Title:</span></b><span style="font-size:12.0pt;line-height:115%;font-family:Calibri;mso-ascii-theme-font:
major-latin;mso-hansi-theme-font:major-latin">
Investigating cell-cell interactions and tumor heterogeneity in lung cancer<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:
Calibri;mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin">The focus of the Jacks lab is to create and utilize genetically engineered mice to model various types
of cancers. These models serve as tools for understanding the critical steps of tumor initiation and progression at a molecular and cellular level. We are currently investigating intratumoral heterogeneity in a well-characterized pre-clinical mouse model of
lung cancer. Cellular heterogeneity poses a major hurdle for effective cancer therapy as cancer cells may depend on distinct survival signals and therefore evade therapy and repopulate the tumor.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:
Calibri;mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin">This UROP project will involve the study of key molecular drivers that contribute to tumor heterogeneity.
The student will examine the functional role of some of these genes by performing various loss-of-function and gain-of-function experiments, both in cancer cell lines and in animals. Furthermore, the student will utilize microscopy to analyze various aspects
of tumor biology.<o:p></o:p></span></p>
<p style="line-height: 13.5pt; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: white; position: static; z-index: auto; background-position: initial initial; background-repeat: initial initial; ">
<b style="mso-bidi-font-weight:
normal"><span style="font-size:12.0pt;font-family:Calibri;mso-ascii-theme-font:
major-latin;mso-hansi-theme-font:major-latin">Prerequisites:</span></b><span style="font-size:12.0pt;font-family:Calibri;mso-ascii-theme-font:major-latin;
mso-hansi-theme-font:major-latin">
Applicants should be highly motivated and willing to work independently. Preference will be given to students with experience performing biological assays. Furthermore, it is encouraged that students take the Biology Project Lab course and/or basic introductory
biology courses (e.g. 7.02). Students applying for this position should be prepared to commit at least 12-14hours per week.
<o:p></o:p></span></p>
<p style="line-height:13.5pt;background:white"><strong><span style="font-size:
12.0pt;font-family:Calibri;mso-ascii-theme-font:major-latin;mso-hansi-theme-font:
major-latin;mso-bidi-font-family:Arial;color:black">Start date:</span></strong><span class="apple-converted-space"><span style="font-size:12.0pt;font-family:Calibri;
mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin;mso-bidi-font-family:
Arial;color:black"> </span></span><span style="font-size:12.0pt;
font-family:Calibri;mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin;
mso-bidi-font-family:Arial;color:black">June
1<sup>st</sup> and continuing into the 2014-2015 Academic Year. <o:p></o:p></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:115%;font-family:Calibri;mso-ascii-theme-font:
major-latin;mso-hansi-theme-font:major-latin"><span style="mso-spacerun:yes"> </span>Contact:</span></b><span style="font-size:
12.0pt;line-height:115%;font-family:Calibri;mso-ascii-theme-font:major-latin;
mso-hansi-theme-font:major-latin">
Interested applicants should email their CV/resumes to Tuomas Tammela (</span><a href="mailto:ttammela@mit.edu"><span style="font-size:12.0pt;line-height:115%;font-family:Calibri;mso-ascii-theme-font:
major-latin;mso-hansi-theme-font:major-latin">ttammela@mit.edu</span></a><span style="font-size:12.0pt;line-height:115%;font-family:Calibri;mso-ascii-theme-font:
major-latin;mso-hansi-theme-font:major-latin">)
</span><span style="font-size:
12.0pt;line-height:115%;font-family:Calibri;mso-ascii-theme-font:major-latin;
mso-fareast-font-family:"Times New Roman";mso-hansi-theme-font:major-latin;
mso-bidi-font-family:Arial;color:black;background:white">highlighting
relevant experience as well as a brief description of their status at MIT.</span><span style="font-size:12.0pt;line-height:115%;font-family:Calibri;mso-ascii-theme-font:
major-latin;mso-fareast-font-family:"Times New Roman";mso-hansi-theme-font:
major-latin;mso-bidi-font-family:"Times New Roman""><o:p></o:p></span></p>
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