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<b style="font-family: arial, sans-serif; font-size: 18px; ">New Biology IAP course for credit or non-credit!</b><span style="font-family: arial, sans-serif; font-size: 13px; "></span>
<div><span style="font-family: arial, sans-serif; font-size: 18px; "><b>Open to undergraduate, graduate students, and postdocs<br>
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<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 18px; "><b>CHEMISTRY AND BIOLOGY OF ANTIBIOTICS</b></span></div>
<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; ">Instructor: Prof. Jason K. Sello, Ph.D.</span></div>
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<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; "><b>Course meeting days</b>: There will be 12 class sessions scheduled on</span></div>
<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; "><span class="" tabindex="0"><span class="">January 6</span></span>, 7, 8, 14, 15, 16, 21, 22, 27, 28, 29, 30</span></div>
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<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; "><b>Time: </b> <span class="" tabindex="0"><span class="">3:30-5pm</span></span></span></div>
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<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; "><b>Location: </b></span><span style="font-size: 14px; ">Building 68-180, except on <span class="" tabindex="0"><span class="">January 6th</span></span>, class will
be held in 68-121</span></div>
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<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; "><b>Course units:</b> 3 unit course: 1-0-2</span></div>
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<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; "><b>Registration:</b></span></div>
<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; ">Register for 7.931 Special Subject in Biology for Graduate Students</span></div>
<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; ">Pre-register for IAP subjects by <span class="" tabindex="0"><span class="">Friday, January 3, 2014 by 5pm</span></span>.</span></div>
<div style="font-family: arial, sans-serif; font-size: 13px; "><span style="font-size: 14px; ">After <span class="" tabindex="0"><span class="">January 3rd</span></span>, course can be added by submitting an add/drop/change form.</span></div>
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<div><span style="font-size: 14px; ">Course can be taken for credit or non-credit. Auditors are welcome.</span></div>
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<div style="font-family: arial, sans-serif; font-size: 13px; "><b style="font-size: 14px; ">Course description:</b></div>
<p class="MsoNormal" style="font-family: arial, sans-serif; font-size: 13px; text-align: justify; ">
<span style="font-size: 11pt; font-family: Arial; ">An antibiotic is defined as a small molecule produced by a microorganism that kills or compromises the growth of another microorganism. These molecules<span style="color: black; "> are likely to be used for
chemical defense in Nature, but they have long been exploited in biological research, biotechnology, and medicine. In this course, we will address the following questions:</span></span></p>
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<span style="font-size: 11pt; font-family: Arial; color: black; "> </span><span class="Apple-style-span" style="font-family: Arial; font-size: 15px; ">Which microorganisms produce antibiotics?</span></div>
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<span style="font-size: 11pt; font-family: Arial; color: black; ">How are antibiotics discovered and structurally characterized?</span></p>
<p class="MsoNormal" style="font-family: arial, sans-serif; font-size: 13px; text-align: justify; ">
<span style="font-size: 11pt; font-family: Arial; color: black; ">How do the major structural classes of antibiotics work?</span></p>
<p class="MsoNormal" style="font-family: arial, sans-serif; font-size: 13px; text-align: justify; ">
<span style="font-size: 11pt; font-family: Arial; color: black; ">What are the bases of antibiotic resistance?</span></p>
<p class="MsoNormal" style="font-family: arial, sans-serif; font-size: 13px; text-align: justify; ">
<span style="font-size: 11pt; font-family: Arial; color: black; ">How are the major structural classes of antibiotics biosynthesized?</span></p>
<p class="MsoNormal" style="font-family: arial, sans-serif; font-size: 13px; text-align: justify; ">
<span style="font-size: 11pt; font-family: Arial; color: black; ">How is antibiotic biosynthesis integrated into microbial physiology?</span></p>
<p class="MsoNormal" style="font-family: arial, sans-serif; font-size: 13px; text-align: justify; ">
<span style="font-size: 11pt; font-family: Arial; color: black; ">How are the major structural classes of antibiotics made by man?</span></p>
<p class="MsoNormal" style="font-family: arial, sans-serif; font-size: 13px; text-align: justify; ">
<span style="font-size: 11pt; font-family: Arial; color: black; ">How are antibiotics used in Nature, the laboratory, and the clinic?</span></p>
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<span style="font-family: arial, helvetica, sans-serif; font-size: 14px; ">This course is designed to highlight the connections between chemistry and biology. </span><span style="font-size: 14px; ">A wide array of topics at the interface of chemistry and biology
will be covered. </span><span style="font-family: arial, helvetica, sans-serif; font-size: 14px; ">It</span><font face="arial, helvetica, sans-serif" style="font-size: 14px; "> is open to students with backgrounds in the biological and/or the physical sciences.
It is expected that</font><span style="font-size: 14px; font-family: arial, helvetica, sans-serif; "> students with strong backgrounds in chemistry will learn fundamental concepts in biology; those with a strong knowledge in biology will learn fundamental
concepts in chemistry. Some f</span><span style="font-size: 14px; font-family: arial, helvetica, sans-serif; ">amiliarity with basic concepts of organic chemistry, biochemistry, and genetics will be assumed.</span></div>
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<div style="font-size: 13px; "><b style="font-size: 14px; ">Course activities: </b></div>
<div style="font-size: 13px; "><span style="font-size: 14px; ">This course includes lectures, in-class discussions, and problem sets. </span></div>
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<div style="font-size: 13px; text-align: justify; "><span style="font-family: arial, helvetica, sans-serif; font-size: 14px; "><b>Instructor: </b>Prof. Jason K. Sello is currently the M. L. K., Jr. Visiting Associate Professor of Biology at MIT and an Associate
Professor in the Department of Chemistry at Brown University. Prior to his appointment at Brown, Prof. Sello was a visiting scientist at the John Innes Centre in Norwich, England and a post-doctoral research fellow at Harvard Medical School with Prof. Christopher
T. Walsh. He earned a Ph.D. in biophysics from Harvard University in 2002 under the supervision of Prof. Stuart L. Schreiber and a B.S. in biology from Morehouse College in 1997. In his independent career, Prof. Sello has been synergistically using experimental
methods from chemistry, molecular biology, biochemistry, and genomics to develop new anti-infectives and biotechnology platforms for the conversion of plant biomass to biofuels and commodity chemicals. At MIT, he is working collaboratively with Prof. Robert
T. Sauer in the Department of Biology on antibacterial agents that act by critically perturbing protein turnover in bacteria. </span></div>
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<div><span style="font-family: arial, helvetica, sans-serif; font-size: 14px; text-align: justify; ">Contact info: Prof. Jason Sello -</span><span style="font-family: arial, helvetica, sans-serif; font-size: 14px; text-align: justify; "> </span><a href="mailto:jsello@mit.edu" target="_blank" style="font-family: arial, helvetica, sans-serif; font-size: 14px; text-align: justify; ">jsello@mit.edu</a> </div>
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