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<span style="font-family:'Helvetica'; font-size:medium"><b>From: </b></span><span style="font-family:'Helvetica'; font-size:medium">"Ralston, Kyle" <<a href="mailto:Kyle.Ralston@deshawresearch.com">Kyle.Ralston@deshawresearch.com</a>><br>
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<span style="font-family:'Helvetica'; font-size:medium"><b>Date: </b></span><span style="font-family:'Helvetica'; font-size:medium">September 15, 2013 7:49:55 PM EDT</span></div>
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<span style="font-family:'Helvetica'; font-size:medium"><b>Subject: </b></span><span style="font-family:'Helvetica'; font-size:medium"><b>D. E. Shaw Research Information Session</b></span></div>
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<span class="x_Apple-style-span" style="font-size:11pt">My name is Kyle Ralston and I’m writing on behalf of D. E. Shaw Research, a computational biochemistry group based in Manhattan. We will be hosting a talk and information session at MIT through the Chemistry
Department on Thursday, September 19 at 5:00 PM in Building 18, room 278 (flyer attached). During the talk we will present an overview of our work and answer any questions students may have about our lab. Our group is quite interdisciplinary and so we would
like to invite students of all degree levels from a variety of fields to attend. Would you be willing to circulate an email announcement to the Biology Department or recommend someone who might be able to help us spread the word about the talk? Below I have
included the logistics of the talk, as well as information about our company and about our speakers for the event. I am happy to answer any questions you may have, and I look forward to hearing from you! Thanks very much for your help.</span></div>
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<div style="font-family:Helvetica; font-size:11pt">Apologies if you’ve already received any notifications about this event, but I thought I’d reach out to you personally in case you hadn’t already received word.</div>
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<div style="font-family:Helvetica; font-size:11pt">Best,</div>
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<div style="font-family:Helvetica; font-size:11pt">Kyle Ralston<br>
Strategic Growth, D. E. Shaw Research<br>
<a href="mailto:Kyle.Ralston@DEShawResearch.com"><font color="blue"><u>Kyle.Ralston@DEShawResearch.com</u></font></a></div>
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D. E. Shaw Research Information Session</b></span></font></span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">Date: Thursday, September 19, 2013</span></font></div>
<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">Time: 5:00 - 6:30 PM</span></font></div>
<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">Location: Building 18, Room 278</span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">Refreshments will be served!</span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt"><b>About The Talk</b></span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">D. E. Shaw Research is an independent research laboratory that conducts basic scientific research in the field of computational biochemistry under the direct scientific
leadership of Dr. David E. Shaw. Our group is currently focusing on molecular simulations involving proteins and other biological macromolecules of potential interest from both a scientific and a pharmaceutical perspective. Members of the lab include computational
chemists and biologists, computer scientists and applied mathematicians, and computer architects and engineers, all working collaboratively within a tightly coupled interdisciplinary research environment.</span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">Our lab has designed and constructed a massively parallel supercomputer called Anton specifically for the execution of molecular dynamics (MD) simulations. Each
Anton computer can simulate a single MD trajectory as much as a millisecond or so in duration -- a timescale at which biologically significant phenomena occur. Anton has already generated the world’s longest MD trajectory.</span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">Join us for an overview of our work on parallel algorithms and machine architectures for high-speed MD simulations and a description of the simulations that have
helped elucidate the dynamics and functional mechanisms of biologically important proteins.</span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt"><b>About The Speakers</b></span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt"><b>John Klepeis</b></span></font></div>
<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">John leads force field development efforts at DESRES and oversees certain external activities of the lab. John earned a Ph.D. in chemical engineering from Princeton
University. He received an M.S. in chemical engineering practice and an S.B. in chemical engineering, with a minor in German language and literature, from MIT. During his time as a Research Assistant and Postdoctoral Research Associate at Princeton, John developed
novel approaches for protein structure prediction and de novo protein design.</span></font></div>
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<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt"><b>Tarun Chitra</b></span></font></div>
<div style="font-family:Helvetica; font-size:11pt"><font size="2"><span style="font-size:10pt">Tarun focuses on analysis of molecular dynamics simulations. Tarun graduated from Cornell University with a B.Eng. in applied engineering physics and a B.A. in mathematics.</span></font></div>
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