<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><br><div><br><div>Begin forwarded message:</div><br class="Apple-interchange-newline"><blockquote type="cite"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium; color:rgba(0, 0, 0, 1);"><b>From: </b></span><span style="font-family:'Helvetica'; font-size:medium;">Rakesh Karmacharya <<a href="mailto:rakesh@broad.mit.edu">rakesh@broad.mit.edu</a>><br></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium; color:rgba(0, 0, 0, 1);"><b>Date: </b></span><span style="font-family:'Helvetica'; font-size:medium;">May 1, 2012 12:08:32 PM EDT</span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium; color:rgba(0, 0, 0, 1);"><b>Subject: </b></span><span style="font-family:'Helvetica'; font-size:medium;"><b>Research technician recruitment</b><br></span></div><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><div class="gmail_quote"><br></div></div></blockquote><div><br></div><div>
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Research/Harvard Medical School is seeking a highly motivated individual to
fill a Research Technician II position to study the neurobiology of
schizophrenia and bipolar disorder using human induced pluripotent stem cells
(iPSCs). </span></span><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:
Calibri;mso-bidi-font-family:Arial;color:#262626">The overall goal is to
discover cellular signatures for schizophrenia and bipolar disorder in
iPSC-derived neurons using phenotypic and gene expression studies.
Signature-based high-throughput screens will then be used to identify novel
small molecule probes to investigate the disease biology of schizophrenia and
bipolar disorder and to provide leads for therapeutic development. </span><span class="pslongeditbox"><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:
Calibri">The work involves generating and characterizing iPSCs from
fibroblasts, differentiating iPSCs along neuronal lineages and developing
image-based and gene-expression based assays to identify disease signatures.
Prior work with human embryonic stem cells/iPS cells is an asset. Applicants
should be familiar with molecular biology techniques (cloning, DNA and RNA
extraction, PCR, RT-PCR, western blotting) and cell biology (cell culture,
immunofluorescence) approaches. Responsibilities will include performing
laboratory research and providing technical support for members of the lab. </span></span><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:
Arial;color:#262626">The project entails close collaboration with the Chemical
Biology Program at the Broad Institute of Harvard and MIT.</span><span class="pslongeditbox"><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:
Calibri"><o:p></o:p></span></span></p><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span class="pslongeditbox"><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:
Calibri"><span style="mso-spacerun:yes"> </span></span></span><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri"><br>
<span class="pslongeditbox">Qualifications: The applicant should have an interest
in cellular and molecular neurobiology with laboratory experience including
standard techniques and cell culture, and preferably good computer skills and
experience with databases. The ideal candidate will possess excellent critical
thinking and organizational skills, pays close attention to detail, is willing
to learn, is comfortable carrying out his/her work independently and enjoys
working in a team environment. Minimum degree and field of knowledge: BS/BA. A
two-year commitment is preferred. <o:p></o:p></span></span></p><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri"><br>
<span class="pslongeditbox">Interested candidates should submit their curriculum
vitae and contact information to: <o:p></o:p></span></span></p><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span class="pslongeditbox"><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:
Calibri">Rakesh Karmacharya, MD, PhD <<a href="mailto:karmacharya@chgr.mgh.harvard.edu">karmacharya@chgr.mgh.harvard.edu</a>></span></span><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri"><br style="mso-special-character:line-break">
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<!--[endif]--><o:p></o:p></span></p>
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