<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
</head>
<body>
<div style="word-wrap:break-word">
<div>
<div>
<div>
<div style="word-wrap:break-word"><span class="x_x_x_Apple-style-span" style="border-collapse:collapse"><span style="background-color:rgb(255,255,255)"><font class="x_x_x_Apple-style-span" face="Arial"><span style="font-size:13px; border-collapse:collapse"><span style="font-size:large"><u>The
MIT Department of Biology and Biology Undergraduate Student Association (BUSA) present:</u></span></span></font></span><span style="background-color:rgb(255,255,255)"><font class="x_x_x_Apple-style-span" face="Arial">
<font><br>
<div style="text-align:center"><span style="border-collapse:collapse"><font class="x_x_x_Apple-style-span" size="6"><i>The Charles "Ned" E. Holt Lecture</i></font></span></div>
</font></font></span></span>
<div>
<div style="border-collapse:collapse; text-align:center"><font class="x_x_x_Apple-style-span" size="6" face="Arial"><b>Mark Krasnow, M.D., Ph.D.</b></font></div>
<div style="border-collapse:collapse; text-align:center"><span style="border-collapse:collapse"><font size="6" face="Arial" color="#ff2617"><i>Tuesday, April 3rd</i></font></span></div>
<div>
<div><span style="font-family:Arial; background-color:rgb(255,255,255)">
<div><i><font class="x_x_x_Apple-style-span" color="#ff2617">
<div style="text-align:center; border-collapse:collapse"><span style="border-collapse:collapse"><font size="6">4 PM</font></span></div>
<div style="text-align:center; border-collapse:collapse"><span style="border-collapse:collapse"><font size="6">32-123</font></span></div>
<div style="text-align:center; border-collapse:collapse"><span style="border-collapse:collapse"><font size="6"><br>
</font></span></div>
</font></i></div>
</span></div>
<div><span class="x_x_x_Apple-style-span" style="border-collapse:collapse"><font class="x_x_x_Apple-style-span" face="Arial" size="4">Refreshments will be provided at 3:45 PM.</font></span></div>
<div><span class="x_x_x_Apple-style-span" style="border-collapse:collapse"><b><font class="x_x_x_Apple-style-span" face="Arial" size="4">SEATING IS LIMITED, PLEASE RSVP TO <a href="mailto:bexec@mit.edu">bexec@mit.edu</a>.</font></b></span></div>
<div><span style="background-color:rgb(255,255,255)">
<div style="display:inline!important">
<div style="border-collapse:collapse; display:inline!important">
<div style="border-collapse:separate; display:inline!important"><span style="border-collapse:collapse"><font class="x_x_x_Apple-style-span" face="Arial" size="4"><br>
</font></span></div>
</div>
</div>
</span></div>
<div><font class="x_x_x_Apple-style-span" face="Arial" size="4"><span style="background-color:rgb(255,255,255)">
<div style="display:inline!important">
<div style="border-collapse:collapse; display:inline!important">
<div style="border-collapse:separate; display:inline!important"><span style="border-collapse:collapse">On Tuesday, April 3rd, <b><a href="http://cmgm.stanford.edu/krasnow/">Dr. Mark Krasnow</a> </b>will be delivering the annual </span></div>
</div>
</div>
</span><span style="background-color:rgb(255,255,255)">
<div style="display:inline!important">
<div style="border-collapse:collapse; display:inline!important">
<div style="border-collapse:separate; display:inline!important"><span style="border-collapse:collapse"><span style="color:rgb(34,34,34)"><a href="https://biology.mit.edu/events/charles_ned_e_holt_lecture"><b>Charles Edward Holt Memorial Lecture</b></a>, on
the topic of</span> "<i>Genetic dissection of lung stem cells and cancer at single cell resolution</i>." </span></div>
</div>
</div>
</span><span class="x_x_x_Apple-style-span" style="line-height:17px">Every year, a distinguished scientist and teacher "interested both in the biological sciences and undergraduate education" is invited to speak before the MIT undergraduate community and the
public at the Holt lecture.</span></font></div>
<div><span style="background-color:rgb(255,255,255)">
<div style="display:inline!important">
<div style="border-collapse:collapse; display:inline!important"><span style="border-collapse:collapse"><span style="border-collapse:separate"><font class="x_x_x_Apple-style-span" face="Arial" size="4"><br>
</font></span></span></div>
</div>
</span></div>
<div><font class="x_x_x_Apple-style-span" face="Arial" size="4"><span style="background-color:rgb(255,255,255)">
<div style="display:inline!important">
<div style="border-collapse:collapse; display:inline!important"><span style="border-collapse:collapse"><span style="border-collapse:separate">Dr. Krasnow<font> is Chair of the Department of Biochemistry at Stanford University School of Medicine, Executive Director
of the Wall Center for Pulmonary Vascular Disease, and a Howard Hughes Medical Institute Investigator. His research is centered around t</font></span></span></div>
</div>
</span><span class="x_x_x_Apple-style-span" style="color:rgb(45,45,45); line-height:18px">he biochemical mechanisms of cell migration, cytoplasmic extension, and cell adhesion during development of the Drosophila tracheal (respiratory) system. The tracheal
system is a network of epithelial tubes that transports oxygen to the tissues, like the lungs and vascular system in mammals. </span><span style="background-color:rgb(255,255,255)">
<div style="display:inline!important">
<div style="border-collapse:collapse; display:inline!important"><span style="border-collapse:separate">His teaching activities focus on the molecular basis of medicine, biochemistry education, as well as research by undergraduate, graduate, and medical students
alike.</span></div>
</div>
</span></font></div>
</div>
</div>
<div><font class="x_x_x_Apple-style-span" face="Arial" size="4"><span style="background-color:rgb(255,255,255)">
<div style="display:inline!important">
<div style="border-collapse:collapse; display:inline!important"><span style="border-collapse:separate"></span></div>
</div>
</span></font></div>
</div>
<div style="word-wrap:break-word">
<div><font class="x_x_x_Apple-style-span" face="Arial" size="4"><span style="background-color:rgb(255,255,255)">
<div style="display:inline!important">
<div style="border-collapse:collapse; display:inline!important"><span style="border-collapse:separate"></span></div>
</div>
</span></font></div>
</div>
</div>
</div>
</div>
</div>
<div style="word-wrap:break-word">
<div>
<div></div>
</div>
<div><span class="x_Apple-style-span" style="border-collapse:separate; color:rgb(0,0,0); font-family:Helvetica; font-style:normal; font-variant:normal; font-weight:normal; letter-spacing:normal; line-height:normal; orphans:2; text-align:auto; text-indent:0px; text-transform:none; white-space:normal; widows:2; word-spacing:0px; font-size:medium"><span class="x_Apple-style-span" style="border-collapse:separate; color:rgb(0,0,0); font-family:Helvetica; font-style:normal; font-variant:normal; font-weight:normal; letter-spacing:normal; line-height:normal; orphans:2; text-indent:0px; text-transform:none; white-space:normal; widows:2; word-spacing:0px; font-size:medium">
<div style="word-wrap:break-word">
<div><br>
</div>
<div><br>
</div>
</div>
</span><br class="x_Apple-interchange-newline">
</span><br class="x_Apple-interchange-newline">
</div>
<br>
</div>
</body>
</html>