<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><div><div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;"><span style="font-family:'Helvetica'; font-size:medium;"><br><span class="Apple-style-span" style="font-size: large; "><span class="Apple-tab-span" style="white-space:pre"> </span>MIT Biology Undergraduate Student Association <b><span style="color: rgb(0, 153, 0);">(<span class="il">BUSA</span>)</span></b> Presents: </span></span></div><font size="4"><br></font><div style="text-align: center;"><b><font size="4">"Get To Know Your Professor" Series</font></b><br>
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</b><br><b><font size="4"><span class="il">Lunch</span> with Professor Laurie Boyer</font></b><br></div><b><font size="4"><br><br></font></b><span style="color: rgb(0, 0, 0);">Date: Wednesday 10/12</span><br style="color: rgb(0, 0, 0);">
<span style="color: rgb(0, 0, 0);">Time: Noon-1pm</span><br style="color: rgb(0, 0, 0);">
<span style="color: rgb(0, 0, 0);">Place: Given upon RSVP<br><br><br>Research Overview: <br></span>Stem cells are essential for metazoan development and for the
maintenance of tissue homeostasis in the adult organism. Embryonic stem
(ES) cells can be derived from the mammalian pre-implantation embryo and
have enormous therapeutic potential because they can propagated <em>in vitro</em>
while maintaining the capacity to give rise to all cell types in the
body. A major challenge in biology is to understand how these
undifferentiated cells execute the diverse gene expression programs that
lead to cellular specification. Chromatin organization is a fundamental
mechanism used by all eukaryotes to compartmentalize the genome into
functional domains in order to interpret the vast amount of genetic
information encoded within the genome. The overall goal of the lab is to
understand how chromatin structure influences gene expression programs
and ultimately cell fate and how failure to establish proper chromatin
states can contribute to disease. To address these questions, we use a
combination of genomic, genetic, biochemical and cell biological tools
to precisely characterize the factors involved in regulating chromatin
structure, to determine how these factors are recruited to genomic
sites, and to investigate how these different regulatory pathways
cooperate to organize the genome. We are particularly interested in how
specific chromosomal domains are assembled and propagated in ES cells,
adult stem cells, and somatic cells. Discovering how gene expression
programs are regulated is required to improve our understanding of
development and disease, and for realizing the therapeutic potential of
stem cells.<br><font size="4"><br><br></font>Open to undergrads of all majors. Space is limited so <font size="4">RSVP to <a href="mailto:bexec@mit.edu" target="_blank">bexec@mit.edu</a></font><br clear="all"><br>-- <br>
Diana Wang<br>Massachusetts Institute of Technology<br>Department of Biology<br><a href="mailto:dgwang@mit.edu">dgwang@mit.edu</a> | 845-235-7545<br>
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