<br><div class="gmail_quote"><div style="word-wrap:break-word"><div><div><br><blockquote type="cite"><div><div style="margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px"><font face="Helvetica" size="4" color="#000000" style="font:14.0px Helvetica;color:#000000"><b>From: </b></font><font face="Helvetica" size="4" style="font:14.0px Helvetica">Hirdesh Uppal <<a href="mailto:uppal.hirdesh@gene.com" target="_blank">uppal.hirdesh@gene.com</a>></font></div>
<div style="margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px"><font face="Helvetica" size="4" color="#000000" style="font:14.0px Helvetica;color:#000000"><b>Date: </b></font><font face="Helvetica" size="4" style="font:14.0px Helvetica">May 6, 2010 1:29:27 PM EDT</font></div>
<div style="margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px"><font face="Helvetica" size="4" color="#000000" style="font:14.0px Helvetica;color:#000000"><b>To: </b></font><font face="Helvetica" size="4" style="font:14.0px Helvetica"><<a href="mailto:erminia@mit.edu" target="_blank">erminia@mit.edu</a>></font></div>
<div style="margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px"><font face="Helvetica" size="4" color="#000000" style="font:14.0px Helvetica;color:#000000"><b>Subject: </b></font><font face="Helvetica" size="4" style="font:14.0px Helvetica"><b>Summer Intern Position at Genentech Inc: South San Francisco</b></font></div>
<div style="margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;min-height:14px"><br></div> </div><span style="border-collapse:separate;color:rgb(0, 0, 0);font-family:'Times New Roman';font-size:medium;font-style:normal;font-variant:normal;font-weight:normal;letter-spacing:normal;line-height:normal;text-align:auto;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px"><div lang="EN-US" link="blue" vlink="#606420">
<div><div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Hello Erminia,</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">We have an opening for a summer intern position at Genentech Inc in<span> </span>South San Francisco. This is a very exciting opportunity for students to be involved at the forefront of human stem cell research. I hope that you can circulate within your department so that interested students may apply. Thanks for your help.</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Regards,</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Hirdesh</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">-------------------------</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><b><u><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial;font-weight:bold">Position Details:</span></font></u></b></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Background: Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide remarkable cellular platforms to better understand human hematopoiesis and to develop clinically applicable hematopoietic cell-based therapies. Over the last decade, hESCs have been utilized to characterize molecular and cellular mechanisms underpinning the differentiation of hematopoietic progenitors and mature, functional hematopoietic cells.</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Project: </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">i) Directed differentiation of human stem cells into the hematopoietic and mesenchymal stem cell lineages</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">ii) Development of in vitro cultures of hematopoietic & mesenchymal stem cells and their different progenitors for use in bone marrow toxicity assays</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Project Details: The identification and use of specific cytokine combinations which support stem cell proliferation and differentiation have been developed which allows the ex vivo generation of mesenchymal & hematopoietic cells for bone marrow toxicity evaluation. The major work in this project will involve successful derivation of hematopoietic & mesenchymal stem cells and further expansion of different lineages of hematopoietic cells requiring the establishment of well-controlled, reproducible and reliable culture conditions. </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Contact:</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">--------------------------------</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Hirdesh Uppal, DVM, PhD.</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Development Sciences,</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Genentech, Inc.</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">1</span></font><font face="Arial"><span style="font-family:Arial"><span> </span>DNA Way,<span> </span>MS</span></font><font face="Arial"><span style="font-family:Arial">#59</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">South San Francisco</span></font><font face="Arial"><span style="font-family:Arial">,<span> </span>CA<span> </span>94080</span></font><font face="Arial"><span style="font-family:Arial"></span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Email:<span> </span><a href="mailto:hirdeshu@gene.com" style="color:blue;text-decoration:underline" target="_blank">hirdeshu@gene.com</a></span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial">Tel: 650-225-7180</span></font></div>
<div style="margin-top:0in;margin-right:0in;margin-bottom:0.0001pt;margin-left:0in;font-size:10pt;font-family:'Times New Roman'"><font size="2" face="Arial"><span style="font-size:10pt;font-family:Arial"> </span></font></div>
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