<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><FONT class="Apple-style-span" face="Garamond" size="6"><SPAN class="Apple-style-span" style="font-size: 24px;">Dr. M. Celeste Simon, of the Abramson Family Cancer Research Center, University of Pennsylvania, will speak on</SPAN></FONT><DIV><FONT class="Apple-style-span" face="Garamond" size="6"><SPAN class="Apple-style-span" style="font-size: 24px;"></SPAN></FONT><BR class="khtml-block-placeholder"><DIV style="text-align: center;"><FONT class="Apple-style-span" face="Garamond" size="6"><SPAN class="Apple-style-span" style="font-size: 24px;"><FONT class="Apple-style-span" color="#0000FF"> "Adaptations to Oxygen Starvation: effects on metabolism, stem cells, and tumor growth."</FONT></SPAN></FONT></DIV><DIV style=""><FONT class="Apple-style-span" face="Garamond" size="6"><SPAN class="Apple-style-span" style="font-size: 24px;"><FONT class="Apple-style-span" color="#000000"><BR class="khtml-block-placeholder"></FONT></SPAN></FONT></DIV><DIV style="text-align: center;"><FONT class="Apple-style-span" face="Garamond" size="6"><SPAN class="Apple-style-span" style="font-size: 24px;"><FONT class="Apple-style-span" color="#000000">March 5, 2007 </FONT></SPAN></FONT></DIV><DIV style="text-align: center;"><FONT class="Apple-style-span" face="Garamond" size="6"><SPAN class="Apple-style-span" style="font-size: 24px;"><FONT class="Apple-style-span" color="#000000">MIT Stata Ctr; 32-123</FONT></SPAN></FONT></DIV><DIV style="text-align: center;"><FONT class="Apple-style-span" face="Garamond" size="6"><SPAN class="Apple-style-span" style="font-size: 24px;"><FONT class="Apple-style-span" color="#000000">4 p.m.</FONT></SPAN></FONT></DIV><DIV style="text-align: center;"><FONT class="Apple-style-span" color="#000000"><FONT class="Apple-style-span" face="Garamond" size="5"><SPAN class="Apple-style-span" style="font-size: 18px;">refreshments at 3:30.</SPAN></FONT></FONT></DIV></DIV></BODY></HTML>