<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#008100"><B>Biology Colloquium</B></FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Monday, December 11, 2006</DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Dr. Tyler Jacks</DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">MIT Center for Cancer Research</DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><B>"Creating Cancer (and Trying to Cure it)"</B></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">32-123 Stata Center Auditorium</DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">4pm (refreshments at 3:30)</DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Hosted by Dr. Phillip Sharp</DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Dr. Jacks is the Director for the Center for Cancer Research, he is also the David H. Koch Professor of Biology, and an Investigator for the Howard Hughes Medical Institute. He earned his Ph.D. in 1988 at the University of California, San Francisco.</DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">The Jacks laboratory is interested in the genetic events that contribute to the development of cancer. The focus of their research is a series of mouse strains engineered to carry mutations in genes known to be involved in human cancer. Using conventional and conditional loss-of-function and gain-of-function mutations in various tumor suppressor genes as well as the K-ras oncogene, they have constructed mouse models of lung cancer, astrocytoma, endometroid ovarian cancer, retinoblastoma, and tumors of the peripheral nervous system. They also study the effects of these mutations on normal embryonic development and use cells derived from mutant animals to study the function of these genes in cell culture models.</DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><A href="http://web.mit.edu/ccr/faculty/pages/jacks.htm">Jacks</A></DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Biology Headquarters</DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Massachusetts Institute of Technology</DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><A href="http://mit.edu/biology/www/">http://mit.edu/biology/www/</A></DIV><DIV style="text-align: left;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><BR class="khtml-block-placeholder"></DIV></BODY></HTML>