<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#008000"><B>Biology Colloquium</B></FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#000000">Monday, December 11, 2006</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><FONT class="Apple-style-span" color="#000000"><BR></FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#000000">Dr. Tyler Jacks</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#000000">MIT Center for Cancer Research</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#000000"><B>"</B></FONT><FONT class="Apple-style-span" color="#000000"><B>Creating Cancer (and Trying to Cure it)</B></FONT><FONT class="Apple-style-span" color="#000000"><B>"</B></FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Tahoma; min-height: 14px; "><FONT class="Apple-style-span" color="#000000"><BR></FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#000000">32-123 Stata Center Auditorium</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#000000">4pm (refreshments at 3:30)</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#000000">Hosted by Dr. Phillip Sharp</FONT></DIV><DIV style="text-align: center;margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" color="#000000"><BR class="khtml-block-placeholder"></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; text-align: center; "><FONT class="Apple-style-span" color="#000000">Dr. Jacks is the Director for the Center for Cancer Research, he is also the </FONT><FONT class="Apple-style-span" color="#000000">David H. Koch Professor of Biology, and an </FONT><FONT class="Apple-style-span" color="#000000">Investigator for the Howard Hughes Medical Institute. He earned his </FONT><FONT class="Apple-style-span" color="#000000">Ph.D. in 1988 at the University of California, San Francisco.</FONT><FONT class="Apple-style-span" color="#000000"></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; text-align: center; "><FONT class="Apple-style-span" color="#000000"><BR class="khtml-block-placeholder"></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; text-align: center; "><FONT class="Apple-style-span" color="#000000">The Jacks laboratory is interested in the genetic events that contribute to the development of cancer. The focus of their research is a series of mouse strains engineered to carry mutations in genes known to be involved in human cancer. Using conventional and conditional loss-of-function and gain-of-function mutations in various tumor suppressor genes as well as the K-ras oncogene, they have constructed mouse models of lung cancer, astrocytoma, endometroid ovarian cancer, retinoblastoma, and tumors of the peripheral nervous system. They also study the effects of these mutations on normal embryonic development and use cells derived from mutant animals to study the function of these genes in cell culture models.</FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; text-align: center; "><FONT class="Apple-style-span" color="#000000"><BR class="khtml-block-placeholder"></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; text-align: center; "><A href="http://web.mit.edu/ccr/faculty/pages/jacks.htm"><FONT class="Apple-style-span" color="#0000FF">Jacks</FONT></A></DIV><BR><DIV><SPAN class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px 0px; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; text-align: auto; -khtml-text-decorations-in-effect: none; text-indent: 0px; -apple-text-size-adjust: auto; text-transform: none; orphans: 2; white-space: normal; widows: 2; word-spacing: 0px; "><DIV>Biology Headquarters</DIV><DIV><BR class="khtml-block-placeholder"></DIV><DIV>Massachusetts Institute of Technology</DIV><DIV><BR class="khtml-block-placeholder"></DIV><DIV><A href="http://mit.edu/biology/www/">http://mit.edu/biology/www/</A></DIV><DIV><BR class="khtml-block-placeholder"></DIV><BR class="Apple-interchange-newline"></SPAN> </DIV><BR></BODY></HTML>